Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 11/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840744 | 0.83 | ADRB2 (0.51) | ADRB2TAAR1CYP1A2CYP3A4CYP2C19 | |
| Hydrochloric Acid SCHEMBL8899662 | 0.78 | ADRB2 (0.63) | ADRB2ABCB11ADRB1DRD2PDE4A | |
| SCHEMBL8531752 | 0.78 | ADRB2 (0.74) | ADRB2ABCB11ADRB1DRD2PDE4A | |
| SCHEMBL8533198 | 0.77 | ADRB2 (0.77) | ADRB2ABCB11ADRB1DRD2PDE4A | |
| SCHEMBL8671939 | 0.77 | ADRB2 (0.51) | ADRB2ABCB11ADRB1DRD2PDE4A | |
| SCHEMBL7828804 | 0.74 | ADRB2 (0.62) | ADRB2ABCB11ADRB1DRD2PDE4A | |
| SCHEMBL8088349 | 0.73 | ABCB11 (0.73) | ADRB2ABCB11ADRB1DRD2PDE4A | |
| SCHEMBL8673879 | 0.73 | ADRB2 (0.53) | ADRB2ABCB11ADRB1DRD2PDE4A | |
| SCHEMBL7837307 | 0.70 | ADRB2 (0.80) | ADRB2ABCB11ADRB1DRD2PDE4A | |
| SCHEMBL7836282 | 0.70 | ADRB2 (0.79) | ADRB2ABCB11ADRB1DRD2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558677-B1 | BIOLOGICALLY ACTIVE AMINES | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-5763465-A | 7-(2-aminoethyl) benzothiazolones | ASTRA PHARMACEUTICALS LIMITED (GB) | 1998-06-09 | — | — | US | disclosed |
| US-5648370-A | 7-(2-aminoethyl) benzothiazolones | ASTRA PHARMACEUTICALS LIMITED (GB) | 1997-07-15 | — | — | US | disclosed |