Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 10/20 | 0.47 |
| ▸ | USP5 | P45974 | 1/20 | 0.44 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL80119 | 1.00 | DDR1 (0.47) | DDR1USP5GPR139TSHRNPSR1 | |
| SCHEMBL77994 | 0.81 | GCK (0.48) | USP5TSHRHPGD | |
| SCHEMBL87330 | 0.81 | GCK (0.48) | USP5TSHRHPGD | |
| SCHEMBL311956 | 0.80 | USP5 (0.68) | USP5TSHRALDH1A1HPGD | |
| SCHEMBL80194 | 0.80 | USP5 (0.68) | USP5TSHRALDH1A1HPGD | |
| SCHEMBL79121 | 0.78 | DDR1 (0.43) | DDR1ALDH1A1 | |
| SCHEMBL79122 | 0.78 | DDR1 (0.43) | DDR1ALDH1A1 | |
| SCHEMBL78193 | 0.77 | USP5 (0.43) | USP5TSHRNPSR1ALDH1A1HPGD | |
| SCHEMBL6385632 | 0.77 | USP5 (0.48) | USP5TSHRNPSR1ALDH1A1 | |
| SCHEMBL79412 | 0.77 | USP5 (0.48) | USP5TSHRNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129381-B2 | Caspase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-06 | — | — | US | disclosed |
| US-20090281128-A1 | CASPASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-11-12 | — | — | US | disclosed |
| US-7553852-B2 | Caspase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-06-30 | — | — | US | disclosed |
| CN-100503572-C | Caspase inhibitors and uses thereof | VERTEX PHARMA (US) | 2009-06-24 | — | — | CN | disclosed |
| CN-1675184-A | Caspase inhibitors and uses thereof | VERTEX PHARMA (US) | 2005-09-28 | — | — | CN | disclosed |
| EP-1539701-A1 | CASPASE INHIBITORS AND USES THEREOF | Vertex Pharmaceuticals Incorporated (US) | 2005-06-15 | — | — | EP | disclosed |
| US-20040072850-A1 | Caspase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2004-04-15 | — | — | US | disclosed |
| WO-2004002961-A1 | CASPASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072850-A1 | Caspase inhibitors and uses thereof | CASP1, CASP5, CASP2 | DDR1 2263/4885USP5 759/4885GPR139 4458/4885 |
| US-20090281128-A1 | CASPASE INHIBITORS AND USES THEREOF | CASP1, CASP5, CASP3 | DDR1 2574/4885USP5 590/4885GPR139 4406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.