Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.66 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.64 |
| ▸ | BCL2 | P10415 | 1/20 | 0.64 |
| ▸ | BID | P55957 | 1/20 | 0.64 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6598140 | 0.91 | CCR2 (0.54) | CCR2MCL1BCL2BIDSRD5A2 | |
| SCHEMBL31159405 | 0.88 | BCL2 (0.66) | CCR2MCL1BCL2BIDSRD5A2 | |
| SCHEMBL6543181 | 0.82 | MCL1 (0.59) | CCR2MCL1BCL2BIDSRD5A2 | |
| SCHEMBL20761835 | 0.82 | BCL2 (0.58) | MCL1BCL2BIDSRD5A2HDAC1 | |
| SCHEMBL6596517 | 0.81 | CCR2 (0.73) | CCR2MCL1BCL2BIDABCB11 | |
| SCHEMBL6542672 | 0.80 | BCL2 (0.59) | CCR2MCL1BCL2BIDSRD5A2 | |
| SCHEMBL7638737 | 0.80 | BCL2 (0.59) | CCR2MCL1BCL2BIDSRD5A2 | |
| SCHEMBL6959828 | 0.80 | CCR2 (1.00) | CCR2MCL1BCL2BIDHDAC1 | |
| SCHEMBL20742924 | 0.80 | SRD5A2 (0.60) | MCL1BCL2BIDSRD5A2HDAC1 | |
| SCHEMBL6953098 | 0.79 | CCR2 (0.75) | CCR2MCL1BCL2BIDABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150952-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046196-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |