Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 2/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.54 |
| ▸ | BCL2 | P10415 | 1/20 | 0.54 |
| ▸ | BID | P55957 | 1/20 | 0.54 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7829429 | 0.91 | CCR2 (0.66) | CCR2MCL1BCL2BIDSRD5A2 | |
| SCHEMBL6595442 | 0.83 | CCR2 (0.55) | CCR2HDAC1HDAC6NOD2NOD1 | |
| SCHEMBL6963990 | 0.83 | CCR2 (0.74) | CCR2MCL1BCL2BIDHDAC1 | |
| SCHEMBL6964954 | 0.82 | CCR2 (0.56) | CCR2NOD2NOD1PTGS2 | |
| SCHEMBL7644066 | 0.81 | BCL2 (0.50) | CCR2MCL1BCL2BIDSRD5A2 | |
| SCHEMBL31159349 | 0.81 | NOD2 (0.61) | MCL1BCL2BIDSRD5A2HDAC1 | |
| SCHEMBL20761835 | 0.80 | BCL2 (0.58) | MCL1BCL2BIDSRD5A2HDAC1 | |
| SCHEMBL20742924 | 0.80 | SRD5A2 (0.60) | MCL1BCL2BIDSRD5A2HDAC1 | |
| SCHEMBL31159405 | 0.80 | BCL2 (0.66) | CCR2MCL1BCL2BIDSRD5A2 | |
| SCHEMBL31159493 | 0.78 | SRD5A2 (0.55) | MCL1BCL2BIDSRD5A2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150952-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-10-27 | — | — | EP | disclosed |
| US-6737435-B1 | ANTIINFLAMMATORY AGENTS; MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) DISEASES | ASTRAZENECA AB (SE) | 2004-05-18 | — | — | US | disclosed |