Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.59 |
| ▸ | BID | P55957 | 1/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.59 |
| ▸ | CCR2 | P41597 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7638737 | 0.92 | BCL2 (0.59) | BCL2BIDMCL1CCR2SRD5A2 | |
| SCHEMBL7644066 | 0.92 | BCL2 (0.50) | BCL2BIDMCL1CCR2SRD5A2 | |
| SCHEMBL6543181 | 0.90 | MCL1 (0.59) | BCL2BIDMCL1CCR2SRD5A2 | |
| SCHEMBL6542674 | 0.88 | BCL2 (0.48) | BCL2BIDMCL1CCR2SRD5A2 | |
| SCHEMBL7641620 | 0.84 | MCL1 (0.52) | BCL2BIDMCL1CCR2SRD5A2 | |
| SCHEMBL7638741 | 0.83 | BCL2 (0.49) | BCL2BIDMCL1CCR2SRD5A2 | |
| SCHEMBL7829429 | 0.80 | CCR2 (0.66) | BCL2BIDMCL1CCR2SRD5A2 | |
| SCHEMBL31159405 | 0.80 | BCL2 (0.66) | BCL2BIDMCL1CCR2SRD5A2 | |
| SCHEMBL7644069 | 0.80 | BCL2 (0.40) | BCL2BIDMCL1SRD5A2NOD2 | |
| SCHEMBL20761835 | 0.74 | BCL2 (0.58) | BCL2BIDMCL1SRD5A2PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6469046-B1 | FABH INHIBITORS WHICH ARE USEFUL AS ANTIBIOTICS FOR THE TREATMENT OF GRAM POSITIVE AND GRAM NEGATIVE BACTERIAL INFECTIONS | SMITHKLINE BEECHAM CORPORATION | 2002-10-22 | — | — | US | claimed |
| EP-1187607-A4 | INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-01-28 | — | — | EP | disclosed |
| US-6469046-B1 | FABH INHIBITORS WHICH ARE USEFUL AS ANTIBIOTICS FOR THE TREATMENT OF GRAM POSITIVE AND GRAM NEGATIVE BACTERIAL INFECTIONS | SMITHKLINE BEECHAM CORPORATION | 2002-10-22 | — | — | US | disclosed |
| EP-1187607-A1 | INDOLE COMPOUNDS | SmithKline Beecham Corporation (US) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000078309-A1 | INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-28 | — | — | WO | disclosed |