Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.40 |
| ▸ | DRD2 | P14416 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 5/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7832946 | 0.80 | CYP2A6 (0.44) | SIGMAR1MAPTLMNATP53 | |
| SCHEMBL7830887 | 0.70 | KDM4E (0.42) | MAPTLMNATP53PKM | |
| SCHEMBL7829992 | 0.69 | SIGMAR1 (0.47) | SIGMAR1DRD2MAPTLMNAPTGS2 | |
| SCHEMBL286590 | 0.68 | KMT2A (0.35) | MAPTLMNACDC7ROCK1DBF4 | |
| SCHEMBL30267491 | 0.64 | PIK3CD (0.46) | MAPTCDC7PIK3CDPIK3CAPIK3CB | |
| SCHEMBL12189104 | 0.64 | TP53 (0.34) | MAPTLMNACDC7ROCK1DBF4 | |
| SCHEMBL286625 | 0.63 | SIGMAR1 (0.36) | SIGMAR1DRD2MAPTLMNACDC7 | |
| SCHEMBL21316072 | 0.62 | MAPT (0.50) | MAPTLMNATP53PKM | |
| SCHEMBL15000221 | 0.61 | RAB9A (0.40) | LMNACDC7TP53PTGS2 | |
| SCHEMBL1003235 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105125547-A | FORUM PHARMACEUTICALS INC | FORUM PHARMACEUTICALS INC | 2015-12-09 | — | — | CN | disclosed |
| CN-102459242-B | Phenoxymethyl heterocyclic compounds | FORUM PHARMACEUTICALS INC. (US) | 2015-08-26 | — | — | CN | disclosed |
| EP-1109799-A1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORPORATION (KR) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000061571-A1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORPORATION (KR) | 2000-10-19 | — | — | WO | disclosed |