Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 6/20 | 0.43 |
| ▸ | LPL | P06858 | 1/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27468872 | 0.79 | SIGMAR1 (0.57) | SIGMAR1DRD2 | |
| SCHEMBL11479263 | 0.76 | SIGMAR1 (0.44) | SIGMAR1DRD2GSTP1PTGER3 | |
| SCHEMBL28042699 | 0.73 | BACE1 (0.50) | SIGMAR1DRD2HPGDKDM4EMAPT | |
| SCHEMBL11314945 | 0.73 | DRD2 (0.42) | SIGMAR1DRD2GSTP1PTGER3LMNA | |
| SCHEMBL7832796 | 0.71 | PTGS2 (0.40) | PTGS1PTGS2HDAC4HDAC2HDAC8 | |
| SCHEMBL7829503 | 0.69 | SIGMAR1 (0.40) | SIGMAR1DRD2LMNAMAPTPTGS2 | |
| SCHEMBL3646655 | 0.67 | GSTP1 (0.52) | GSTP1PTGER3ALDH1A1KDM4ENOTUM | |
| SCHEMBL4269525 | 0.66 | GSTP1 (0.42) | SIGMAR1DRD2GSTP1PTGER3LPL | |
| SCHEMBL5013872 | 0.65 | ESR1 (0.71) | GSTP1ALDH1A1KDM4EMAPTACMSD | |
| SCHEMBL15902840 | 0.65 | ESR1 (0.71) | GSTP1ALDH1A1KDM4EMAPTACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-A1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORPORATION (KR) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000061571-A1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORPORATION (KR) | 2000-10-19 | — | — | WO | disclosed |