Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CDC7 | O00311 | 3/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7837582 | 0.81 | EGFR (0.35) | KDRNPC1EGFRMAPT | |
| SCHEMBL7838604 | 0.80 | EGFR (0.35) | LMNAKDRRXFP1ALDH1A1EGFR | |
| SCHEMBL8813155 | 0.73 | NPC1 (0.32) | ALDH1A1NPC1CYP2C19EGFR | |
| SCHEMBL7822327 | 0.72 | RXRB (0.41) | LMNACDC7DBF4ALDH1A1NPC1 | |
| SCHEMBL8815271 | 0.72 | F2 (0.36) | ALDH1A1NPC1MAPTMEN1KMT2A | |
| SCHEMBL7829575 | 0.72 | MAOB (0.47) | LMNAKDR | |
| SCHEMBL7347464 | 0.65 | TOP1 (0.49) | NPC1MEN1KMT2A | |
| SCHEMBL5485288 | 0.65 | NPC1 (0.38) | LMNAALDH1A1NPC1EGFRMAPT | |
| SCHEMBL9430440 | 0.64 | HCAR2 (0.48) | NPC1MEN1KMT2A | |
| SCHEMBL9792739 | 0.63 | CYP11B1 (0.41) | LMNANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802914-B1 | ARYL- AND HETEROARYL- PURINE AND PYRIDOPYRIMIDINE DERIVATIVES | PHARMACIA & UPJOHN SPA (IT) | 2001-06-06 | — | — | EP | claimed |