Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7839823 | 0.83 | EGFR (0.36) | EGFRENPP1CYP1A2KMT2ALMNA | |
| SCHEMBL8814662 | 0.82 | EGFR (0.42) | EGFRPDE5AKMT2ALMNAALDH1A1 | |
| SCHEMBL8816236 | 0.77 | EGFR (0.57) | EGFRKMT2AMAPTKDR | |
| SCHEMBL7821637 | 0.75 | PDE5A (0.40) | EGFRPDE5ACYP1A2KMT2ALMNA | |
| SCHEMBL7836815 | 0.74 | MAOB (0.43) | EGFRPDE5A | |
| SCHEMBL8815271 | 0.67 | F2 (0.36) | KMT2AALDH1A1MAPT | |
| SCHEMBL7350494 | 0.62 | ALDH1A1 (0.37) | CYP1A2KMT2ALMNAALDH1A1MAPT | |
| SCHEMBL7837582 | 0.61 | EGFR (0.35) | EGFRMAPTKDR | |
| SCHEMBL21339635 | 0.61 | EGFR (0.47) | EGFRENPP1CYP1A2KMT2ALMNA | |
| SCHEMBL30940152 | 0.61 | EGFR (0.47) | EGFRENPP1CYP1A2KMT2AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802914-B1 | ARYL- AND HETEROARYL- PURINE AND PYRIDOPYRIMIDINE DERIVATIVES | PHARMACIA & UPJOHN SPA (IT) | 2001-06-06 | — | — | EP | claimed |
| EP-0802914-A1 | ARYL AND HETEROARYL PURINE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-10-29 | — | — | EP | claimed |
| WO-1997018212-A1 | ARYL AND HETEROARYL PURINE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-05-22 | — | — | WO | claimed |