Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 18/20 | 0.47 |
| ▸ | CA1 | P00915 | 17/20 | 0.47 |
| ▸ | CA5A | P35218 | 4/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.47 |
| ▸ | CA12 | O43570 | 16/20 | 0.46 |
| ▸ | CA9 | Q16790 | 16/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4881585 | 0.71 | CA12 (0.57) | CA2CA1CA5ACA5BCA12 | |
| SCHEMBL17358810 | 0.71 | CHRNA7 (0.58) | CA2CA1CA5ACA5BCA12 | |
| SCHEMBL671068 | 0.71 | NOTUM (0.44) | CA2CA1CA12CA9KDM4E | |
| SCHEMBL2903090 | 0.71 | NOTUM (0.48) | KDM4EALDH1A1LMNA | |
| SCHEMBL2752440 | 0.71 | NOTUM (0.44) | CA2CA1CA5ACA5BKDM4E | |
| SCHEMBL430176 | 0.70 | GAA (0.42) | KDM4EPTGS2 | |
| SCHEMBL202948 | 0.68 | CA2 (0.81) | CA2CA1CA5ACA5BCA12 | |
| SCHEMBL7229570 | 0.68 | NOTUM (0.44) | CA2CA12CA9KDM4EALDH1A1 | |
| SCHEMBL18109146 | 0.68 | LMNA (0.67) | CA2CA1CA5ACA5BCA12 | |
| SCHEMBL18118202 | 0.68 | NOTUM (0.55) | CA2CA1CA5ACA5BCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131288-A1 | PYRROLIDINE DERIVATIVES-CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-09-12 | — | — | EP | disclosed |
| US-6166015-A | Pyrrolidine derivatives-CCR-3 receptor antagonists | SYNTEX (U.S.A.) INC. (US) | 2000-12-26 | — | — | US | disclosed |
| WO-2000031032-A1 | PYRROLIDINE DERIVATIVES-CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-02 | — | — | WO | disclosed |