SCHEMBL7830375

SCHEMBL7830375

CCOC(=O)CCCC(C#N)(c1ccccc1)c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
OPRM1 P35372 3/20 0.50
KCNA3 P22001 3/20 0.50
SMN1; SMN2 Q16637 2/20 0.48
POLB P06746 1/20 0.47
CYP2D6 P10635 2/20 0.47
DRD2 P14416 1/20 0.47
DRD4 P21917 1/20 0.47
DRD3 P35462 1/20 0.47
CYP4F2 P78329 2/20 0.45
CYP4A11 Q02928 2/20 0.45
ALDH1A1 P00352 1/20 0.44
ALOX5 P09917 1/20 0.43
CCR1 P32246 1/20 0.43
TOP2A P11388 1/20 0.42
CCR3 P51677 1/20 0.41
RAB9A P51151 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C19 P33261 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8046235 0.96 OPRM1 (0.49) OPRM1KCNA3SMN1; SMN2POLBCYP2D6
SCHEMBL8044856 0.95 OPRM1 (0.48) OPRM1KCNA3SMN1; SMN2POLBCYP2D6
SCHEMBL8049892 0.95 OPRM1 (0.48) OPRM1KCNA3SMN1; SMN2POLBCYP2D6
SCHEMBL7826967 0.92 KCNA3 (0.52) OPRM1KCNA3SMN1; SMN2POLBCYP2D6
SCHEMBL8047298 0.88 OPRM1 (0.44) OPRM1KCNA3SMN1; SMN2POLBCYP2D6
SCHEMBL8314746 0.84 OPRM1 (0.47) OPRM1KCNA3SMN1; SMN2POLBCYP2D6
SCHEMBL7828708 0.84 OPRM1 (0.47) OPRM1KCNA3SMN1; SMN2POLBCYP2D6
SCHEMBL8311559 0.84 OPRM1 (0.49) OPRM1KCNA3SMN1; SMN2POLBCYP2D6
SCHEMBL8046383 0.84 CYP4F2 (0.40) OPRM1KCNA3SMN1; SMN2CYP4F2CYP4A11
SCHEMBL8044989 0.84 SMN1; SMN2 (0.40) OPRM1KCNA3SMN1; SMN2POLBCYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0712845-B1 Amine compounds, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2001-10-17 EP disclosed
EP-0679642-B1 Condensed heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1999-11-10 EP disclosed
US-5654296-A HORMONE INHIBITOR; NERVOUS SYSTEM DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-08-05 US disclosed
WO-1997024325-A1 DIPHENYLMETHANE DERIVATIVES AS MIP-1α/RANTES RECEPTOR ANTAGONISTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-07-10 WO disclosed
US-5633248-A GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS, DIARYLALKYLIDENEDIAMINES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-05-27 US disclosed
US-5607939-A CALCIUM ANTAGONIST, GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONIST AND MONOAMINEU UPTAKE INHIBITORS FOR CENTRAL NERVOUS SYSTEM DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-03-04 US disclosed
EP-0712845-A1 Amine compounds, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-05-22 EP disclosed
EP-0679642-A1 Condensed heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-11-02 EP disclosed