SCHEMBL8314746

SCHEMBL8314746

CCOC(=O)CCC(C#N)(c1ccccc1)c1ccc(F)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OPRM1 P35372 3/20 0.47
KCNA3 P22001 3/20 0.47
SMN1; SMN2 Q16637 3/20 0.44
POLB P06746 1/20 0.43
CYP2D6 P10635 1/20 0.43
DRD2 P14416 1/20 0.43
DRD4 P21917 1/20 0.43
DRD3 P35462 1/20 0.43
CCR1 P32246 1/20 0.42
MAPT P10636 2/20 0.39
ALDH1A1 P00352 1/20 0.39
KCNN4 O15554 2/20 0.38
NPSR1 Q6W5P4 2/20 0.38
LMNA P02545 2/20 0.38
MEN1 O00255 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
KMT2A Q03164 1/20 0.38
CYP4F2 P78329 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5438206 0.95 MAPT (0.42) OPRM1KCNA3SMN1; SMN2POLBMAPT
SCHEMBL7826967 0.92 KCNA3 (0.52) OPRM1KCNA3SMN1; SMN2POLBCYP2D6
SCHEMBL8047298 0.91 OPRM1 (0.44) OPRM1KCNA3SMN1; SMN2POLBCYP2D6
SCHEMBL7828708 0.88 OPRM1 (0.47) OPRM1KCNA3SMN1; SMN2POLBCYP2D6
SCHEMBL7824585 0.86 OPRM1 (0.46) OPRM1KCNA3SMN1; SMN2POLBCYP2D6
SCHEMBL8053206 0.85 FAAH (0.44) OPRM1KCNA3CCR1MAPTALDH1A1
SCHEMBL7830375 0.84 OPRM1 (0.50) OPRM1KCNA3SMN1; SMN2POLBCYP2D6
SCHEMBL8046235 0.83 OPRM1 (0.49) OPRM1KCNA3SMN1; SMN2POLBCYP2D6
SCHEMBL1508237 0.83 MAPT (0.45) OPRM1KCNA3POLBMAPTALDH1A1
SCHEMBL8049892 0.82 OPRM1 (0.48) OPRM1KCNA3SMN1; SMN2POLBCYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0679642-B1 Condensed heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1999-11-10 EP disclosed
US-5654296-A HORMONE INHIBITOR; NERVOUS SYSTEM DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-08-05 US disclosed
US-5607939-A CALCIUM ANTAGONIST, GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONIST AND MONOAMINEU UPTAKE INHIBITORS FOR CENTRAL NERVOUS SYSTEM DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-03-04 US disclosed
EP-0679642-A1 Condensed heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-11-02 EP disclosed