Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27007785 | 0.91 | HSD11B1 (0.42) | HSD11B1TYMPALDH1A1S1PR1MAPT | |
| SCHEMBL27478471 | 0.79 | HSD11B1 (0.33) | HSD11B1LMNAALDH1A1GSK3BDYRK1A | |
| SCHEMBL14804396 | 0.78 | ALDH1A1 (0.47) | HSD11B1ALDH1A1MAPTNPC1AVPR1A | |
| SCHEMBL24484316 | 0.77 | HPGD (0.42) | HSD11B1LMNAALDH1A1NPC1TSHR | |
| SCHEMBL3348744 | 0.75 | TSHR (0.50) | HSD11B1LMNAALDH1A1MAPTUSP2 | |
| SCHEMBL15026023 | 0.74 | HSD11B1 (0.36) | HSD11B1ALDH1A1NPC1AVPR1A | |
| SCHEMBL4303038 | 0.73 | ALDH1A1 (0.55) | TYMPLMNAALDH1A1S1PR1MAPT | |
| SCHEMBL27007672 | 0.73 | HSD11B1 (0.41) | HSD11B1ALDH1A1 | |
| SCHEMBL14077016 | 0.73 | HSD11B1 (0.40) | HSD11B1ALDH1A1USP2CYP3A4 | |
| SCHEMBL12377819 | 0.72 | LMNA (0.53) | HSD11B1LMNAALDH1A1NPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799226-B1 | TETRACYCLIC SPIRO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-02-07 | — | — | EP | disclosed |
| US-5972951-A | Tetracyclic spiro compounds, process for their preparation and their use as 5HT1D receptor antagonists | SMITHKLINE BEECHAM PLC (GB) | 1999-10-26 | — | — | US | disclosed |
| WO-1996019477-A1 | TETRACYCLIC SPIRO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |