Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816728 | 0.82 | HDAC3 (0.47) | SMN1; SMN2MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL9325465 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL18457436 | 0.80 | MEN1 (0.55) | SMN1; SMN2MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL11572252 | 0.79 | MEN1 (0.53) | SMN1; SMN2MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL7829210 | 0.77 | TP53 (0.59) | SMN1; SMN2MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL7829213 | 0.77 | TP53 (0.59) | SMN1; SMN2MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL7827581 | 0.76 | KMT2A (0.46) | SMN1; SMN2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL294596 | 0.71 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL10099720 | 0.71 | MEN1 (0.62) | SMN1; SMN2MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL8725847 | 0.71 | ADRA2C (0.55) | SMN1; SMN2MEN1KMT2ACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686636-B1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA CO (JP) | 2001-04-04 | — | — | EP | disclosed |
| US-5840895-A | INTERMEDIATES FOR ANTIALLERGENS | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1998-11-24 | — | — | US | disclosed |
| US-5686442-A | ANTIALLERGENS | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1997-11-11 | — | — | US | disclosed |
| EP-0686636-A1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-12-13 | — | — | EP | disclosed |