Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | F9 | P00740 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | CBFB | Q13951 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834212 | 0.93 | MAOA (0.45) | MAOAMAOBF9CYP11B1CYP11B2 | |
| SCHEMBL7830649 | 0.93 | MAOA (0.44) | MAOAMAOBF9CYP11B1CYP11B2 | |
| SCHEMBL7832659 | 0.91 | F9 (0.42) | MAOAMAOBF9CYP11B1CYP11B2 | |
| SCHEMBL7834220 | 0.86 | MAOA (0.48) | MAOAMAOBF9CYP11B1CYP11B2 | |
| SCHEMBL7831669 | 0.84 | F9 (0.40) | MAOAMAOBF9CYP11B1CYP11B2 | |
| SCHEMBL7832665 | 0.83 | CBFB (0.49) | MAOAMAOBF9CYP11B1CYP11B2 | |
| SCHEMBL7837220 | 0.83 | NPC1 (0.43) | MAOAMAOBF9CYP11B1CYP11B2 | |
| SCHEMBL7832837 | 0.82 | MAOA (0.42) | MAOAMAOBF9CYP11B1CYP11B2 | |
| SCHEMBL7836267 | 0.82 | MAOA (0.42) | MAOAMAOBF9CYP11B1CYP11B2 | |
| SCHEMBL7822535 | 0.81 | CYP19A1 (0.45) | MAOAMAOBF9CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894795-B1 | Benzimidazole, benzoxazole and benzothiazole derivatives, their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-06-06 | — | — | EP | disclosed |
| EP-0894795-A1 | Benzimidazole, benzoxazole and benzothiazole derivatives, their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-02-03 | — | — | EP | disclosed |