Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | CDC25B | P30305 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831361 | 0.87 | L3MBTL1 (0.51) | L3MBTL1TSHRCYP2D6MEN1KMT2A | |
| SCHEMBL7837993 | 0.85 | KDM4E (0.50) | L3MBTL1TSHRPOLBMEN1KMT2A | |
| SCHEMBL7192766 | 0.81 | CYP2D6 (0.58) | L3MBTL1TSHRNR4A1NR4A2NR4A3 | |
| SCHEMBL7543178 | 0.80 | CYP2D6 (0.56) | L3MBTL1TSHRNR4A1NR4A2NR4A3 | |
| SCHEMBL7543175 | 0.78 | NR4A1 (0.49) | L3MBTL1NR4A1NR4A2NR4A3CYP2D6 | |
| SCHEMBL5127180 | 0.75 | L3MBTL1 (0.46) | L3MBTL1TSHRPOLBMEN1KMT2A | |
| SCHEMBL16833128 | 0.75 | KDM4E (0.51) | POLBMEN1KMT2AMAPTTDP1 | |
| SCHEMBL7195634 | 0.74 | NR4A1 (0.49) | L3MBTL1NR4A1NR4A2NR4A3CYP2D6 | |
| SCHEMBL4006546 | 0.74 | DHODH (0.67) | CYP2D6POLBMEN1KMT2AMAPT | |
| SCHEMBL31533134 | 0.73 | NR4A1 (0.59) | NR4A1NR4A2NR4A3CYP2D6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097137-A1 | N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000002859-A1 | N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | disclosed |