Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831310 | 0.85 | L3MBTL1 (0.53) | KDM4EALDH1A1HPGDL3MBTL1MEN1 | |
| SCHEMBL21822146 | 0.84 | CA2 (0.53) | KDM4EALDH1A1HPGDNPSR1SCN9A | |
| SCHEMBL21822221 | 0.84 | ALDH1A1 (0.51) | KDM4EALDH1A1HPGDNPSR1SCN9A | |
| SCHEMBL7831361 | 0.84 | L3MBTL1 (0.51) | KDM4EALDH1A1HPGDNPSR1L3MBTL1 | |
| SCHEMBL21822300 | 0.83 | KDM4E (0.50) | KDM4EALDH1A1HPGDNPSR1SCN9A | |
| SCHEMBL21822187 | 0.81 | KDM4E (0.43) | KDM4EALDH1A1HPGDNPSR1SCN9A | |
| SCHEMBL9413713 | 0.80 | KDM4E (0.47) | KDM4EALDH1A1HPGDNPSR1SCN9A | |
| SCHEMBL28557136 | 0.77 | TCF4 (0.57) | KDM4EALDH1A1SCN9AMEN1KMT2A | |
| SCHEMBL21822261 | 0.76 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDNPSR1SCN9A | |
| SCHEMBL15936293 | 0.75 | ALDH1A1 (0.58) | KDM4EALDH1A1HPGDNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097137-A1 | N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000002859-A1 | N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | disclosed |