Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831310 | 0.87 | L3MBTL1 (0.53) | L3MBTL1TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7837993 | 0.84 | KDM4E (0.50) | L3MBTL1TSHRMEN1KMT2ACA1 | |
| SCHEMBL11185952 | 0.72 | VCAM1 (0.54) | L3MBTL1TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL396042 | 0.71 | L3MBTL1 (0.46) | L3MBTL1TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5127180 | 0.71 | L3MBTL1 (0.46) | L3MBTL1TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL22747378 | 0.71 | CA12 (0.49) | L3MBTL1SMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL2154152 | 0.71 | ALDH1A1 (0.44) | L3MBTL1MEN1KMT2APLK1KDM4E | |
| SCHEMBL3914053 | 0.71 | CDC25B (0.60) | MEN1KMT2APLK1NQO2KDM4E | |
| SCHEMBL21822221 | 0.71 | ALDH1A1 (0.51) | TSHRMEN1KMT2ACA1CA2 | |
| SCHEMBL9568593 | 0.70 | L3MBTL1 (0.48) | L3MBTL1TSHRSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097137-A1 | N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000002859-A1 | N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | disclosed |