Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | F9 | P00740 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7829229 | 0.89 | LTA4H (0.39) | CDK2CCNE1KDM4C | |
| SCHEMBL7832591 | 0.87 | PRKAB2 (0.35) | CDK2CCNE1IKBKB | |
| SCHEMBL7832723 | 0.84 | CDK2 (0.42) | CDK2CCNE1KDM4CHTR1ADRD2 | |
| SCHEMBL7832880 | 0.83 | CDK2 (0.41) | CDK2CCNE1KDM4CIKBKBHTR1A | |
| SCHEMBL7830382 | 0.83 | KDM5A (0.40) | KDM4C | |
| SCHEMBL7831747 | 0.81 | GABRA1 (0.36) | HTR1ADRD2TYK2 | |
| SCHEMBL7831370 | 0.81 | PDE10A (0.42) | KDM4C | |
| SCHEMBL7829058 | 0.81 | KDM4C (0.41) | CDK2CCNE1KDM4CIKBKBHTR1A | |
| SCHEMBL7820807 | 0.79 | KDM4C (0.41) | CDK2CCNE1KDM4CTYK2 | |
| SCHEMBL7835058 | 0.79 | TUBB1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820997-B1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2001-07-25 | — | — | EP | disclosed |
| US-5985882-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-11-16 | — | — | US | disclosed |
| EP-0820997-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-28 | — | — | EP | disclosed |