Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 14/20 | 0.56 |
| ▸ | ABCC8 | Q09428 | 14/20 | 0.56 |
| ▸ | KCNJ11 | Q14654 | 14/20 | 0.56 |
| ▸ | KCNJ8 | Q15842 | 14/20 | 0.56 |
| ▸ | GALK1 | P51570 | 1/20 | 0.47 |
| ▸ | GPR174 | Q9BXC1 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836312 | 0.91 | ABCC9 (0.66) | ABCC9ABCC8KCNJ11KCNJ8GPR174 | |
| SCHEMBL7835453 | 0.85 | ABCC9 (0.67) | ABCC9ABCC8KCNJ11KCNJ8GPR174 | |
| SCHEMBL7835588 | 0.85 | KDM4E (0.61) | ABCC9ABCC8KCNJ11KCNJ8GALK1 | |
| SCHEMBL7832437 | 0.84 | GPR174 (0.59) | ABCC9ABCC8KCNJ11KCNJ8GPR174 | |
| SCHEMBL7824313 | 0.84 | GPR174 (0.60) | ABCC9ABCC8KCNJ11KCNJ8GPR174 | |
| SCHEMBL7834709 | 0.83 | ABCC9 (0.68) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7835762 | 0.82 | GPR174 (0.66) | ABCC9ABCC8KCNJ11KCNJ8GALK1 | |
| SCHEMBL7836378 | 0.82 | FFAR3 (0.56) | ABCC9ABCC8KCNJ11KCNJ8GALK1 | |
| SCHEMBL7836158 | 0.82 | ABCC9 (0.84) | ABCC9ABCC8KCNJ11KCNJ8GPR174 | |
| SCHEMBL6908843 | 0.81 | ABCC9 (0.52) | ABCC9ABCC8KCNJ11KCNJ8GALK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665834-B1 | QUINOLONE AND ACRIDINONE DERIVATIVES FOR THE TREATMENT OF URINARY INCONTINENCE | ASTRAZENECA AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| US-5622964-A | ADMINISTERING 4,6,7,8-TETRAHYDRO-5(1H)-QUINOLONE DERIVATIVE TO TREAT ASTHMA IN MAMMALS | ZENECA LIMITED (GB) | 1997-04-22 | — | — | US | disclosed |
| US-5455253-A | For urinary incontinence | ZENECA LIMITED (GB) | 1995-10-03 | — | — | US | disclosed |
| WO-1994008966-A1 | QUINOLONE AND ACRIDINONE DERIVATIVES FOR THE TREATMENT OF URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1994-04-28 | — | — | WO | disclosed |