Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 3/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | USP1 | O94782 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 3/20 | 0.33 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.33 |
| ▸ | BIRC3 | Q13489 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7814997 | 0.83 | CHRNA7 (0.43) | OPRL1DPP4HTR6CHRNA7HTR2B | |
| SCHEMBL29675238 | 0.79 | OPRL1 (0.45) | OPRL1DPP4HTR6CHRNA7HTR2B | |
| SCHEMBL6002215 | 0.79 | OPRL1 (0.45) | OPRL1DPP4HTR6CHRNA7HTR2B | |
| SCHEMBL7687240 | 0.76 | CHRNA7 (0.60) | OPRL1CHRNA7 | |
| SCHEMBL7678337 | 0.76 | CHRNA7 (0.60) | OPRL1CHRNA7 | |
| SCHEMBL7686991 | 0.76 | CHRNA7 (0.60) | OPRL1CHRNA7 | |
| SCHEMBL7663736 | 0.76 | HCRTR1 (0.49) | CHRNA7 | |
| SCHEMBL7827208 | 0.75 | HCRTR1 (0.54) | OPRL1 | |
| SCHEMBL7837293 | 0.75 | HTR6 (0.57) | OPRL1DPP4HTR6CHRNA7 | |
| SCHEMBL7824788 | 0.75 | HTR6 (0.57) | OPRL1DPP4HTR6CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140891-A1 | 1,4-DIAZACYCLOHEPTANE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040574-A1 | 1,4-DIAZACYCLOHEPTANE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2000-07-13 | — | — | WO | disclosed |