Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.31 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.31 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.31 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.31 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CCNH | P51946 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831770 | 0.85 | PDE10A (0.43) | PDE10ALOXL2CDK7CDK9CDK2 | |
| SCHEMBL7833635 | 0.82 | LOXL2 (0.48) | PDE10ALOXL2CDK7CDK9CDK2 | |
| SCHEMBL7829335 | 0.81 | PDE10A (0.38) | PDE10ALOXL2CDK7CDK9CDK2 | |
| SCHEMBL7821057 | 0.81 | LOXL2 (0.37) | PDE10ALOXL2CDK7CDK9CDK2 | |
| SCHEMBL7832213 | 0.80 | LOXL2 (0.38) | PDE10ALOXL2 | |
| SCHEMBL7832772 | 0.80 | LOXL2 (0.35) | PDE10ALOXL2CDK7CDK9CDK2 | |
| SCHEMBL7831750 | 0.79 | PDE10A (0.37) | PDE10ACDK7CDK9CDK2CDK13 | |
| SCHEMBL7830054 | 0.78 | LOXL2 (0.37) | PDE10ALOXL2 | |
| SCHEMBL7831956 | 0.77 | LOXL2 (0.45) | PDE10ALOXL2 | |
| SCHEMBL7831183 | 0.77 | S1PR4 (0.35) | PDE10ALOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820997-B1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2001-07-25 | — | — | EP | disclosed |
| US-5985882-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-11-16 | — | — | US | disclosed |
| EP-0820997-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-28 | — | — | EP | disclosed |