Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.33 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.33 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK7 | P50613 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.30 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.30 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831770 | 0.88 | PDE10A (0.43) | LOXL2PDE10ACDK2CDK7CDK9 | |
| SCHEMBL7832213 | 0.88 | LOXL2 (0.38) | LOXL2PDE10AKCNN1KCNN2KCNN3 | |
| SCHEMBL7831956 | 0.88 | LOXL2 (0.45) | LOXL2PDE10AKCNN1KCNN2KCNN3 | |
| SCHEMBL7830054 | 0.84 | LOXL2 (0.37) | LOXL2PDE10AKCNN1KCNN2KCNN3 | |
| SCHEMBL7832017 | 0.83 | HTR2C (0.39) | LOXL2KCNN1KCNN2KCNN3CDK2 | |
| SCHEMBL7833191 | 0.82 | PDE10A (0.36) | LOXL2PDE10ACDK2CDK7CDK9 | |
| SCHEMBL7830272 | 0.80 | GABRA1 (0.39) | LOXL2 | |
| SCHEMBL7831627 | 0.80 | LOXL2 (0.50) | LOXL2PDE10AKCNN1KCNN2KCNN3 | |
| SCHEMBL7831183 | 0.78 | S1PR4 (0.35) | LOXL2PDE10AKCNN3MAPT | |
| SCHEMBL7820734 | 0.78 | LOXL2 (0.48) | LOXL2PDE10AKCNN1KCNN2KCNN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820997-B1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2001-07-25 | — | — | EP | disclosed |
| US-5985882-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-11-16 | — | — | US | disclosed |
| EP-0820997-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-28 | — | — | EP | disclosed |