Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 9/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847205 | 0.93 | PTGS2 (0.47) | DHODHKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL7843978 | 0.91 | KDM4E (0.48) | DHODHKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL7833260 | 0.88 | PTGS2 (0.53) | DHODHKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL7843373 | 0.87 | PTGDR2 (0.46) | RAB9AMAPTALDH1A1MEN1HTT | |
| SCHEMBL7842533 | 0.83 | PTGS2 (0.49) | DHODHKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL7847201 | 0.83 | PTGS2 (0.64) | DHODHKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL7845455 | 0.81 | PTGDR2 (0.46) | NPC1RAB9AMAPTALDH1A1MEN1 | |
| SCHEMBL7839772 | 0.79 | PTGDR2 (0.48) | SMN1; SMN2NPC1RAB9AMAPTMEN1 | |
| SCHEMBL7843975 | 0.77 | PTGS2 (0.56) | DHODHKDM4ESMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7843369 | 0.74 | CCNA2 (0.52) | SMN1; SMN2MAPTMEN1KMT2APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |