Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 12/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842533 | 0.92 | PTGS2 (0.49) | KDM4EALDH1A1LMNADHODHPTGS2 | |
| SCHEMBL7833262 | 0.91 | DHODH (0.46) | KDM4EALDH1A1LMNADHODHPTGS2 | |
| SCHEMBL7839772 | 0.87 | PTGDR2 (0.48) | PTGS2MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7843975 | 0.86 | PTGS2 (0.56) | KDM4EALDH1A1LMNADHODHPTGS2 | |
| SCHEMBL7847205 | 0.83 | PTGS2 (0.47) | KDM4EALDH1A1LMNADHODHPTGS2 | |
| SCHEMBL7842530 | 0.81 | PTGS2 (0.68) | KDM4EALDH1A1LMNADHODHPTGS2 | |
| SCHEMBL2696746 | 0.80 | DHODH (0.64) | KDM4EALDH1A1LMNADHODHMAPT | |
| SCHEMBL7832496 | 0.79 | KMT2A (0.51) | KDM4EALDH1A1PTGS2MAPTSMN1; SMN2 | |
| SCHEMBL7843373 | 0.79 | PTGDR2 (0.46) | ALDH1A1PTGS2MAPTRAB9APTGDR2 | |
| SCHEMBL7833260 | 0.78 | PTGS2 (0.53) | KDM4EALDH1A1LMNADHODHPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |