Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 7/20 | 0.48 |
| ▸ | CA9 | Q16790 | 4/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842530 | 0.92 | PTGS2 (0.68) | PTGS2ALDH1A1LMNAKDM4EDHODH | |
| SCHEMBL7833260 | 0.90 | PTGS2 (0.53) | PTGS2ALDH1A1LMNAKDM4EMEN1 | |
| SCHEMBL7843978 | 0.86 | KDM4E (0.48) | PTGS2ALDH1A1LMNAKDM4EMEN1 | |
| SCHEMBL7839771 | 0.86 | CA1 (0.54) | PTGS2MEN1KMT2ACA9CA1 | |
| SCHEMBL2696746 | 0.82 | DHODH (0.64) | ALDH1A1LMNAKDM4EMEN1KMT2A | |
| SCHEMBL207160 | 0.81 | DHODH (0.69) | PTGS2ALDH1A1LMNAKDM4EMEN1 | |
| SCHEMBL7847201 | 0.81 | PTGS2 (0.64) | PTGS2ALDH1A1LMNAKDM4EDHODH | |
| SCHEMBL7842533 | 0.81 | PTGS2 (0.49) | PTGS2ALDH1A1LMNAKDM4EMEN1 | |
| SCHEMBL7843751 | 0.78 | PTGDR2 (0.59) | PTGS2MEN1KMT2ACA9CA1 | |
| SCHEMBL5725174 | 0.78 | CCNA2 (0.78) | MEN1KMT2ACCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |