Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 4/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | NOS2 | P35228 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14125389 | 0.89 | KARS1 (0.63) | KARS1NOS2KMT2AMEN1POLB | |
| SCHEMBL7108041 | 0.83 | KDM4E (0.56) | KARS1NOS2KMT2AMEN1POLB | |
| SCHEMBL8277604 | 0.83 | KDM4D (0.60) | KARS1NOS2KMT2AMEN1POLB | |
| SCHEMBL15830578 | 0.82 | NOS2 (0.56) | KARS1HRH3NOS2KMT2AMEN1 | |
| SCHEMBL18386507 | 0.81 | KDM4E (0.58) | KARS1NOS2KMT2AMEN1POLB | |
| SCHEMBL1755683 | 0.80 | KARS1 (1.00) | KARS1 | |
| SCHEMBL11961829 | 0.80 | NOS2 (0.57) | KARS1NOS2KMT2AMEN1POLB | |
| SCHEMBL24709836 | 0.80 | KDM4D (0.54) | KARS1NOS2KMT2AMEN1POLB | |
| SCHEMBL7832301 | 0.80 | HRH3 (0.51) | KARS1HRH3NOS2STK17AFERMT2 | |
| SCHEMBL8277611 | 0.80 | SMN1; SMN2 (0.51) | KARS1NOS2KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124821-A1 | COMPOUNDS | AstraZeneca AB (SE) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000027842-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2000-05-18 | — | — | WO | disclosed |
| EP-0113572-B1 | PYRIDINE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-02-03 | — | — | EP | disclosed |
| EP-0112707-B1 | AMINOPYRIMIDINONE DERIVATIVES AS HISTAMINE H1-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-11-04 | — | — | EP | disclosed |
| US-4652650-A | Pyridylaminoalkylamine intermediates | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-03-24 | — | — | US | disclosed |
| US-4548940-A | Pyridylaminoalkylaminopyrimidones useful as histamine H1 -antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-10-22 | — | — | US | disclosed |
| US-4547506-A | 2-Pyridylaminoakylamino-4-pyrimidones useful as histamine H1 -antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-10-15 | — | — | US | disclosed |
| EP-0113572-A2 | Pyridine derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-07-18 | — | — | EP | disclosed |
| EP-0112707-A2 | Aminopyrimidinone derivatives as histamine H1-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-07-04 | — | — | EP | disclosed |