Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.35 |
| ▸ | DUT | P33316 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7830614 | 0.79 | DGAT1 (0.36) | DGAT1NPC1ADORA2BADORA2A | |
| SCHEMBL7835528 | 0.79 | DGAT1 (0.37) | DGAT1NPC1ADORA2BADORA2AMAPT | |
| SCHEMBL7833747 | 0.78 | DGAT1 (0.36) | DGAT1NPC1ADORA2BADORA2AMAPT | |
| SCHEMBL7832680 | 0.77 | DGAT1 (0.35) | DGAT1NPC1ADORA2BADORA2AMAPT | |
| SCHEMBL7821630 | 0.76 | NPC1 (0.34) | DGAT1NPC1ADORA2BADORA2A | |
| SCHEMBL200911 | 0.69 | NPC1 (0.41) | DGAT1DUTNPC1 | |
| SCHEMBL29341474 | 0.69 | DUT (0.38) | DGAT1DUTNPC1 | |
| SCHEMBL7830409 | 0.69 | MAPK14 (0.44) | NPC1ADORA2B | |
| SCHEMBL29341472 | 0.69 | DGAT1 (0.40) | DGAT1DUTNPC1 | |
| SCHEMBL7821648 | 0.68 | DUT (0.63) | DUT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-5859014-A | USEFUL IN TREATMENT OF DISEASES INVOLVING DIRECTLY OR INDIRECTLY AN OBSTRUCTION OF THE LOWER URINARY TRACT, SUCH ASBENIGN PROSTATE HYPERPLASIA | SYNTEX (U.S.A.) INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |