Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7835528 | 0.87 | DGAT1 (0.37) | DGAT1MAPTPDE4APDE4BPDE4C | |
| SCHEMBL7830614 | 0.87 | DGAT1 (0.36) | DGAT1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10479182 | 0.86 | KMT2A (0.40) | DGAT1KMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL7832680 | 0.85 | DGAT1 (0.35) | DGAT1KMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL7821630 | 0.84 | NPC1 (0.34) | DGAT1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10479196 | 0.81 | KMT2A (0.39) | DGAT1KMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL10479241 | 0.79 | KMT2A (0.37) | KMT2AALDH1A1LMNAMEN1KDM4E | |
| SCHEMBL7833520 | 0.78 | DGAT1 (0.35) | DGAT1MAPTADORA2BADORA2ANPC1 | |
| SCHEMBL10479252 | 0.69 | LMNA (0.44) | DGAT1KMT2ALMNAKDM4E | |
| SCHEMBL7830021 | 0.68 | NPC1 (0.32) | ADORA2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-5859014-A | USEFUL IN TREATMENT OF DISEASES INVOLVING DIRECTLY OR INDIRECTLY AN OBSTRUCTION OF THE LOWER URINARY TRACT, SUCH ASBENIGN PROSTATE HYPERPLASIA | SYNTEX (U.S.A.) INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |