Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.61 |
| ▸ | MAOB | P27338 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GALR2 | O43603 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TXNRD1 | Q16881 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2305462 | 0.83 | MAOA (0.54) | MAOAMAOBLMNAGALR2POLB | |
| SCHEMBL2306805 | 0.83 | TXNRD1 (0.54) | LMNAGALR2POLBTXNRD1MAPT | |
| SCHEMBL13730216 | 0.82 | MAOA (0.57) | MAOAMAOBLMNAPOLBMAPT | |
| SCHEMBL7834233 | 0.82 | MAOA (0.49) | MAOAMAOBTXNRD1MAPTNPC1 | |
| SCHEMBL7833656 | 0.80 | LMNA (0.46) | MAOAMAOBLMNAGALR2POLB | |
| SCHEMBL29535900 | 0.80 | MAOA (0.51) | MAOAMAOBPOLBTXNRD1MAPT | |
| SCHEMBL22719062 | 0.80 | MAOA (0.51) | MAOAMAOBPOLBTXNRD1MAPT | |
| SCHEMBL11362288 | 0.80 | MAOA (0.51) | MAOAMAOBLMNATXNRD1MAPT | |
| SCHEMBL11362292 | 0.80 | MAOA (0.51) | MAOAMAOBLMNATXNRD1MAPT | |
| SCHEMBL10743303 | 0.80 | MAOA (0.49) | MAOAMAOBLMNATXNRD1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0676398-B1 | Heterocyclic compounds having anti-diabetic activity, their preparation and their use | SANKYO CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-6117893-A | Heterocyclic compounds having anti-diabetic activity and their use | SANKYO COMPANY, LIMITED (JP) | 2000-09-12 | — | — | US | disclosed |
| EP-1022274-A1 | Oxazolidinedione and Thiazolidinedione derivatves, their preparation and their use | Sankyo Company Limited (JP) | 2000-07-26 | — | — | EP | disclosed |
| US-5977365-A | HYPOGLYCEMIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1999-11-02 | — | — | US | disclosed |
| US-5962470-A | Heterocyclic compounds having anti-diabetic activity and their use | SANKYO COMPANY, LIMITED (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5834501-A | TREATING DIABETES OR HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5739345-A | HYPOGLYCEMIC AND ANTIDIABETIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1998-04-14 | — | — | US | disclosed |
| US-5624935-A | ANTIDIABETIC AGENTS, HYPOGLYCEMIC AGENTS OR ANTILIPEMIC AGENTS | SANKYO COMPANY, LIMITED | 1997-04-29 | — | — | US | disclosed |
| EP-0676398-A2 | Heterocyclic compounds having anti-diabetic activity, their preparation and their use | SANKYO COMPANY LIMITED (JP) | 1995-10-11 | — | — | EP | disclosed |
| EP-0257399-B1 | HAIR DYEING COMPOSITION | Beratungslabor für die kosmetische und pharmazeutische Industrie Dipl.-Ing. Karlheinz Schrader (DE) | 1991-01-02 | — | — | EP | disclosed |
| EP-0136730-B1 | 2-AMINONITROPYRIDINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | RÜTGERSWERKE AKTIENGESELLSCHAFT (DE) | 1988-04-27 | — | — | EP | disclosed |
| EP-0257399-A2 | Hair dyeing composition | Beratungslabor für die kosmetische und pharmazeutische Industrie Dipl.-Ing. Karlheinz Schrader (DE) | 1988-03-02 | — | — | EP | disclosed |
| EP-0137524-B1 | HAIR DYEING COMPOSITIONS | RÜTGERSWERKE AKTIENGESELLSCHAFT (DE) | 1988-01-20 | — | — | EP | disclosed |
| US-4567272-A | Pyrrole containing 2-aminonitropyridine derivatives | RUTGERSWERKE AKTIENGESELLSCHAFT (DE) | 1986-01-28 | — | — | US | disclosed |
| EP-0137524-A1 | Hair dyeing compositions | RÜTGERSWERKE AKTIENGESELLSCHAFT (DE) | 1985-04-17 | — | — | EP | disclosed |
| EP-0136730-A1 | 2-Aminonitropyridine derivatives and process for the preparation thereof | RÜTGERSWERKE AKTIENGESELLSCHAFT (DE) | 1985-04-10 | — | — | EP | disclosed |