Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR174 | Q9BXC1 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | GALK1 | P51570 | 1/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7835633 | 0.83 | ALDH1A1 (0.60) | GPR174KMT2AMEN1L3MBTL1GAA | |
| SCHEMBL7833898 | 0.83 | KDM4E (0.60) | GPR174KMT2AMEN1L3MBTL1GAA | |
| SCHEMBL2451845 | 0.82 | CACNA1D (0.69) | GPR174KMT2AMEN1L3MBTL1GAA | |
| SCHEMBL7833283 | 0.82 | GPR174 (0.76) | GPR174KMT2AMEN1L3MBTL1GAA | |
| SCHEMBL7837406 | 0.81 | FFAR3 (0.53) | GPR174KMT2AMEN1L3MBTL1GAA | |
| SCHEMBL7838163 | 0.80 | KMT2A (0.53) | GPR174KMT2AMEN1L3MBTL1GAA | |
| SCHEMBL13425486 | 0.79 | KMT2A (0.59) | GPR174KMT2AMEN1L3MBTL1GAA | |
| SCHEMBL8876634 | 0.77 | ALDH1A1 (0.58) | GPR174KMT2AMEN1L3MBTL1GAA | |
| SCHEMBL7836338 | 0.77 | ABCC9 (0.53) | GPR174L3MBTL1GAASMN1; SMN2CACNA1D | |
| SCHEMBL7835762 | 0.77 | GPR174 (0.66) | GPR174KMT2AMEN1L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665834-B1 | QUINOLONE AND ACRIDINONE DERIVATIVES FOR THE TREATMENT OF URINARY INCONTINENCE | ASTRAZENECA AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| US-5622964-A | ADMINISTERING 4,6,7,8-TETRAHYDRO-5(1H)-QUINOLONE DERIVATIVE TO TREAT ASTHMA IN MAMMALS | ZENECA LIMITED (GB) | 1997-04-22 | — | — | US | disclosed |
| US-5455253-A | For urinary incontinence | ZENECA LIMITED (GB) | 1995-10-03 | — | — | US | disclosed |
| WO-1994008966-A1 | QUINOLONE AND ACRIDINONE DERIVATIVES FOR THE TREATMENT OF URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1994-04-28 | — | — | WO | disclosed |