Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 4/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ASPH | Q12797 | 1/20 | 0.49 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 3/20 | 0.48 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16991862 | 0.85 | KDM4E (0.56) | KDM4EASPHKDM8 | |
| SCHEMBL20715524 | 0.77 | NOS2 (0.50) | KDM4EPSMB1NOS2ALDH1A1HPGD | |
| SCHEMBL9488233 | 0.77 | DHODH (0.55) | SMN1; SMN2ALDH1A1MAPK1KMT2A | |
| SCHEMBL20715522 | 0.77 | BDKRB1 (0.51) | BDKRB1KDM5BKDM4EASPHKDM8 | |
| SCHEMBL10488645 | 0.75 | SMN1; SMN2 (0.73) | KDM5BPPARGSMN1; SMN2ALDH1A1ALOX15 | |
| SCHEMBL11563231 | 0.74 | EGFR (0.54) | KDM4EPSMB1SMN1; SMN2NOS2ALDH1A1 | |
| SCHEMBL8009873 | 0.74 | KDM4E (0.54) | KDM4ESMN1; SMN2ALDH1A1HPGDKMT2A | |
| SCHEMBL6168145 | 0.74 | KDM5B (0.66) | KDM5BKDM4EASPHKDM8ALDH1A1 | |
| SCHEMBL2475860 | 0.71 | CYP1A2 (0.49) | KDM5BKDM4EPSMB1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1585596 | 0.71 | KLKB1 (0.51) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784622-B1 | NAPHTHYRIDINONE DERIVATIVES | KNOLL GMBH (DE) | 2001-11-21 | — | — | EP | disclosed |
| US-5854257-A | Naphthyridinone derivatives | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-12-29 | — | — | US | disclosed |
| EP-0784622-A1 | NAPHTHYRIDINONE DERIVATIVES | Knoll AG (DE) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996011199-A1 | NAPHTHYRIDINONE DERIVATIVES | KNOLL AKTIENGESELLSCHAFT (DE) | 1996-04-18 | — | — | WO | disclosed |