Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | CA1 | P00915 | 2/20 | 0.61 |
| ▸ | CA2 | P00918 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | CDC7 | O00311 | 1/20 | 0.59 |
| ▸ | EEF2K | O00418 | 1/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.59 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.59 |
| ▸ | CDK2 | P24941 | 1/20 | 0.59 |
| ▸ | AKT1 | P31749 | 1/20 | 0.59 |
| ▸ | AKT2 | P31751 | 1/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18870862 | 0.89 | FFAR4 (0.67) | HTR6KMT2ACA1CA2HTT | |
| SCHEMBL2240551 | 0.86 | HTR6 (0.73) | HTR6KMT2ACA1CA2HTT | |
| SCHEMBL1417537 | 0.85 | CA1 (0.71) | HTR6KMT2ACA1CA2HTT | |
| SCHEMBL2240008 | 0.85 | CA1 (0.71) | HTR6KMT2ACA1CA2HTT | |
| SCHEMBL7836889 | 0.85 | HTR6 (0.71) | HTR6KMT2ACA1CA2HTT | |
| SCHEMBL14838614 | 0.84 | FFAR4 (0.70) | KMT2ACA1CA2ALDH1A1CYP3A4 | |
| SCHEMBL3272443 | 0.84 | FFAR4 (0.70) | ALDH1A1MAPTTDP1LMNA | |
| SCHEMBL7838817 | 0.84 | HTR6 (1.00) | HTR6KMT2ACA1CA2HTT | |
| Hydrochloric Acid SCHEMBL8043483 | 0.82 | HTR6 (0.97) | HTR6KMT2ACA1CA2HTT | |
| SCHEMBL14414968 | 0.82 | LMNA (0.61) | KMT2ACA1CA2CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902840-B1 | Planographic printing plate precursor | FUJIFILM CORP (JP) | 2011-07-06 | — | — | EP | disclosed |
| WO-2011022393-A2 | PHOSPHATIDYLCHOLINE TRANSFER PROTEIN INHIBITORS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2011-02-24 | — | — | WO | disclosed |
| EP-1902840-A2 | Planographic printing plate precursor | FUJIFILM Corporation (JP) | 2008-03-26 | — | — | EP | disclosed |
| US-7198877-B2 | Heat-sensitive lithographic printing plate precursor | AGFA-GEVAERT (BE) | 2007-04-03 | — | — | US | disclosed |
| US-7198877-B2 | Heat-sensitive lithographic printing plate precursor | AGFA-GEVAERT (BE) | 2007-04-03 | — | — | US | disclosed |
| EP-0815861-B1 | Sulphonamides and their use | HOFFMANN LA ROCHE (CH) | 2001-09-19 | — | — | EP | disclosed |
| US-6030976-A | SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; CENTRAL NERVOUS SYSTEM DISORDERS; ALZHEIMER'S DISEASE, PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, MEMORY DISORDERS, PARKINSON'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS AND HUNTINGTON'S DISEASE | HOFFMAN-LA ROCHE INC. (US) | 2000-02-29 | — | — | US | disclosed |
| US-5998665-A | THERAPY FOR NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-12-07 | — | — | US | disclosed |
| US-5939451-A | INDOL-4-YL-BENZENESULFONAMIDES AS ACTIVE MATERIAL TREATING MALARIA, BACTERIAL INFECTION, NEUROLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-08-17 | — | — | US | disclosed |
| US-5932599-A | 4-AMINO-N-(PYRIDINYL-4-YL)-BENZENESULFONAMIDES AS ACTIVE MATERIAL TREATING MALARIA, BACTERIAL INFECTION, NEUROLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0815861-A1 | Sulphonamides and their use | F. HOFFMANN-LA ROCHE AG (CH) | 1998-01-07 | — | — | EP | disclosed |