Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 13/20 | 1.00 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841561 | 0.83 | PTGS2 (0.71) | PTGS2PTGS1ROCK2GSK3B | |
| SCHEMBL7841871 | 0.79 | PTGS2 (1.00) | PTGS2PTGS1CDK2 | |
| SCHEMBL7841503 | 0.76 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL216750 | 0.76 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL11368657 | 0.74 | PTGS2 (0.65) | PTGS2PTGS1ROCK2GSK3BMAPT | |
| SCHEMBL7505035 | 0.73 | PTGS2 (0.57) | PTGS2PTGS1CDK2MAPT | |
| SCHEMBL7832876 | 0.72 | PTGS2 (0.93) | PTGS2PTGS1 | |
| SCHEMBL7846478 | 0.72 | PTGS2 (0.56) | PTGS2PTGS1ROCK2GSK3B | |
| SCHEMBL6170748 | 0.71 | PTGS2 (0.55) | PTGS2PTGS1LMNA | |
| SCHEMBL7501679 | 0.71 | PTGS2 (0.55) | PTGS2PTGS1CDK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |