Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | CBFB | Q13951 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | F9 | P00740 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834574 | 0.92 | CYP11B1 (0.51) | CYP11B1CYP11B2MAOAMAOBCBFB | |
| SCHEMBL7832392 | 0.86 | CBFB (0.47) | CYP11B1CYP11B2MAOAMAOBCBFB | |
| SCHEMBL7821991 | 0.86 | NPC1 (0.55) | CYP11B1CYP11B2MAOAMAOBCBFB | |
| Hydrochloric Acid SCHEMBL8155594 | 0.85 | NPC1 (0.54) | CYP11B1CYP11B2MAOAMAOBCBFB | |
| SCHEMBL7833700 | 0.85 | CBFB (0.43) | CYP11B1CYP11B2CBFBFGFR1FLT1 | |
| SCHEMBL7831108 | 0.84 | SMN1; SMN2 (0.55) | CYP11B1CYP11B2MAOAMAOBCBFB | |
| Hydrochloric Acid SCHEMBL8142735 | 0.83 | SMN1; SMN2 (0.54) | CYP11B1CYP11B2MAOAMAOBCBFB | |
| SCHEMBL7840889 | 0.83 | MAOA (0.48) | CYP11B1CYP11B2MAOAMAOBCBFB | |
| SCHEMBL7822236 | 0.82 | TNIK (0.45) | CBFBFGFR1FLT1SMN1; SMN2NPC1 | |
| SCHEMBL7833328 | 0.82 | MAOA (0.52) | CYP11B1CYP11B2MAOAMAOBCBFB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894795-B1 | Benzimidazole, benzoxazole and benzothiazole derivatives, their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-06-06 | — | — | EP | disclosed |
| US-6040327-A | INHIBITORS OF INTERLEUKINS; TREATING RHEUMATOID ARTHRITIS OR ARTHROSIS | ADIR ET COMPAGNIE (FR) | 2000-03-21 | — | — | US | disclosed |
| EP-0894795-A1 | Benzimidazole, benzoxazole and benzothiazole derivatives, their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-02-03 | — | — | EP | disclosed |