Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | F9 | P00740 | 1/20 | 0.40 |
| ▸ | GRK6 | P43250 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834577 | 0.85 | CYP11B1 (0.51) | CBFBCYP3A4CYP2D6FGFR1FLT1 | |
| SCHEMBL7832392 | 0.83 | CBFB (0.47) | CBFBCYP3A4CYP2D6FGFR1FLT1 | |
| SCHEMBL7821991 | 0.83 | NPC1 (0.55) | CBFBCYP3A4CYP2D6FGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL8155594 | 0.82 | NPC1 (0.54) | CBFBCYP3A4CYP2D6FGFR1FLT1 | |
| SCHEMBL7822236 | 0.81 | TNIK (0.45) | CBFBFGFR1FLT1F9ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8143148 | 0.81 | TNIK (0.44) | CBFBFGFR1FLT1F9ALDH1A1 | |
| SCHEMBL7833681 | 0.78 | ADH5 (0.48) | CBFBCYP3A4CYP2D6TBXAS1LMNA | |
| SCHEMBL7834574 | 0.77 | CYP11B1 (0.51) | CBFBCYP3A4CYP2D6LMNAMAPK1 | |
| SCHEMBL7832389 | 0.76 | ENPP2 (0.47) | CBFBCYP3A4CYP2D6FGFR1FLT1 | |
| SCHEMBL7821732 | 0.75 | RAB9A (0.58) | CBFBCYP3A4CYP2D6FGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894795-B1 | Benzimidazole, benzoxazole and benzothiazole derivatives, their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-06-06 | — | — | EP | disclosed |
| US-6040327-A | INHIBITORS OF INTERLEUKINS; TREATING RHEUMATOID ARTHRITIS OR ARTHROSIS | ADIR ET COMPAGNIE (FR) | 2000-03-21 | — | — | US | disclosed |
| EP-0894795-A1 | Benzimidazole, benzoxazole and benzothiazole derivatives, their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-02-03 | — | — | EP | disclosed |