Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8479576 | 1.00 | SLC6A2 (0.52) | SLC6A2SLC6A4TMEM97SIGMAR1CHRNA7 | |
| SCHEMBL7834371 | 1.00 | SLC6A2 (0.52) | SLC6A2SLC6A4TMEM97SIGMAR1CHRNA7 | |
| SCHEMBL4637754 | 0.82 | TMEM97 (0.51) | SLC6A2SLC6A4TMEM97SIGMAR1MEN1 | |
| SCHEMBL2075913 | 0.82 | TMEM97 (0.51) | SLC6A2SLC6A4TMEM97SIGMAR1MEN1 | |
| SCHEMBL11472512 | 0.80 | CHRM2 (0.49) | TMEM97SIGMAR1KDM4EMEN1ALDH1A1 | |
| SCHEMBL6945022 | 0.79 | SLC6A2 (0.63) | SLC6A2SLC6A4CHRNA7TDP1L3MBTL1 | |
| SCHEMBL10034629 | 0.79 | SLC6A2 (0.63) | SLC6A2SLC6A4CHRNA7TDP1L3MBTL1 | |
| SCHEMBL32667248 | 0.74 | CHRNB2 (0.48) | CHRNA7CYP3A4 | |
| SCHEMBL12201661 | 0.74 | TMEM97 (0.49) | TMEM97SIGMAR1MEN1KMT2A | |
| SCHEMBL28773466 | 0.74 | TMEM97 (0.38) | SLC6A2SLC6A4TMEM97SIGMAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265409-B1 | ANTIINFLAMMATORY AGENTS | ASTRAZENECA AB (SE) | 2001-07-24 | — | — | US | disclosed |
| EP-0984961-B1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| US-6143751-A | Pyridine derivatives and pharmaceutical compositions containing them | ASTRAZENECA UK LIMITED (GB) | 2000-11-07 | — | — | US | disclosed |
| US-5977105-A | Compounds | ASTRA PHARMAEUTICALS LTD. (GB) | 1999-11-02 | — | — | US | disclosed |