Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12165522 | 0.76 | ATM (0.77) | ATMLMNASMN1; SMN2PDK2PDK4 | |
| SCHEMBL7834463 | 0.76 | PGR (0.59) | ATMLMNASMN1; SMN2PDK2PDK4 | |
| SCHEMBL28010729 | 0.72 | ATM (0.48) | ATMLMNASMN1; SMN2PDK2PDK4 | |
| SCHEMBL28010767 | 0.72 | ALDH1A1 (0.67) | ATMLMNASMN1; SMN2PDK2PDK4 | |
| SCHEMBL11430300 | 0.72 | PDK2 (0.59) | LMNASMN1; SMN2PDK2PDK4ALDH1A1 | |
| SCHEMBL7836579 | 0.69 | PDK2 (0.60) | LMNASMN1; SMN2PDK2PDK4ALDH1A1 | |
| SCHEMBL11442529 | 0.68 | PDK2 (0.53) | ATMLMNASMN1; SMN2PDK2PDK4 | |
| SCHEMBL24281081 | 0.67 | SMN1; SMN2 (0.62) | ATMLMNASMN1; SMN2PDK2PDK4 | |
| SCHEMBL3244982 | 0.66 | ATM (0.58) | ATMLMNASMN1; SMN2PDK2PDK4 | |
| SCHEMBL7835297 | 0.66 | PDK2 (0.50) | LMNASMN1; SMN2PDK2PDK4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780388-B1 | 5HT1Dalpha and 5HT2A ligands | LILLY CO ELI (GB) | 2001-08-16 | — | — | EP | disclosed |
| US-5773448-A | NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY LIMITED (GB) | 1998-06-30 | — | — | US | disclosed |
| EP-0780388-A1 | 5HT1Dalpha and 5HT2A ligands | LILLY INDUSTRIES LIMITED (GB) | 1997-06-25 | — | — | EP | disclosed |