Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.41 |
| ▸ | EDNRB | P24530 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CTSZ | Q9UBR2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7821006 | 0.91 | ALDH1A1 (0.45) | ALDH1A1RAB9AMAPTL3MBTL1PDE1A | |
| SCHEMBL7830610 | 0.89 | SLC10A2 (0.47) | ALDH1A1RAB9AMAPTL3MBTL1KDM4E | |
| SCHEMBL7830548 | 0.88 | SLC10A2 (0.46) | ALDH1A1RAB9AMAPTL3MBTL1KDM4E | |
| Hydrochloric Acid SCHEMBL8138537 | 0.88 | SLC10A2 (0.46) | ALDH1A1RAB9AMAPTL3MBTL1KDM4E | |
| SCHEMBL7821036 | 0.88 | MAPT (0.40) | ALDH1A1RAB9AMAPTL3MBTL1KDM4E | |
| SCHEMBL7821104 | 0.87 | NPC1 (0.44) | ALDH1A1RAB9AMAPTL3MBTL1KDM4E | |
| SCHEMBL9563414 | 0.83 | ALDH1A1 (0.41) | ALDH1A1RAB9AMAPTL3MBTL1KDM4E | |
| SCHEMBL8131246 | 0.82 | MAPT (0.41) | ALDH1A1RAB9AMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL9563431 | 0.82 | SMN1; SMN2 (0.46) | ALDH1A1RAB9AMAPTL3MBTL1PDE1A | |
| SCHEMBL9563462 | 0.82 | ALDH1A1 (0.40) | ALDH1A1RAB9AMAPTL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567107-B1 | Quinoline and quinazoline derivatives for treating arthritis | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-11-21 | — | — | EP | claimed |
| US-5948782-A | ANTIINFLAMMATORY AGENT; RHEUMATIC DISEASES | TAKEDA CHEMICAL (JP) | 1999-09-07 | — | — | US | claimed |
| EP-0567107-A1 | Quinoline and quinazoline derivatives for treating arthritis | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-27 | — | — | EP | claimed |
| EP-0567107-B1 | Quinoline and quinazoline derivatives for treating arthritis | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-11-21 | — | — | EP | disclosed |
| EP-0567107-A1 | Quinoline and quinazoline derivatives for treating arthritis | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-27 | — | — | EP | disclosed |