Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 3/20 | 0.81 |
| ▸ | CTSL | P07711 | 3/20 | 0.81 |
| ▸ | SIRT2 | Q8IXJ6 | 11/20 | 0.78 |
| ▸ | MAOB | P27338 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | THPO | P40225 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10983488 | 0.90 | CTSV (1.00) | CTSVCTSLSIRT2MEN1KMT2A | |
| SCHEMBL7834264 | 0.86 | CTSV (0.60) | CTSVCTSLSIRT2KMT2ALMNA | |
| SCHEMBL10934405 | 0.86 | SIRT2 (0.76) | CTSVCTSLSIRT2MAOBMEN1 | |
| SCHEMBL7844745 | 0.84 | CTSV (0.59) | CTSVCTSLSIRT2MAOBMEN1 | |
| SCHEMBL27438967 | 0.82 | SIRT2 (0.78) | CTSVCTSLSIRT2MEN1KMT2A | |
| SCHEMBL7844457 | 0.81 | AKR1C3 (0.66) | CTSVCTSLSIRT2MEN1KMT2A | |
| SCHEMBL27322834 | 0.81 | MAOB (0.67) | CTSVCTSLSIRT2MAOBMEN1 | |
| SCHEMBL10986767 | 0.81 | CTSV (0.70) | CTSVCTSLSIRT2MEN1KMT2A | |
| SCHEMBL27438028 | 0.80 | CTSV (0.66) | CTSVCTSLSIRT2MAOBMEN1 | |
| SCHEMBL10599853 | 0.79 | MEN1 (0.79) | CTSVCTSLSIRT2MAOBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783505-B1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2001-03-07 | — | — | EP | disclosed |
| CN-1046731-C | Pyrrolo [2,3-d ] pyrimidines and their use | NOVARTIS AG (CH) | 1999-11-24 | — | — | CN | disclosed |
| US-5869485-A | Pyrrolo 2,3-d!pyrimidines and their use | NOVARTIS FINANCE CORP. (US) | 1999-02-09 | — | — | US | disclosed |
| CN-1164234-A | Pyrrolo [2, 3-d ] pyrimidines and their use | NOVARTIS AG (CH) | 1997-11-05 | — | — | CN | disclosed |
| EP-0783505-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | Novartis AG (CH) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996010028-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 1996-04-04 | — | — | WO | disclosed |