Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 3/20 | 0.59 |
| ▸ | CTSL | P07711 | 3/20 | 0.59 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.57 |
| ▸ | MAOB | P27338 | 3/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7835152 | 0.84 | CTSV (0.81) | CTSVCTSLSIRT2MAOBMEN1 | |
| SCHEMBL7844741 | 0.77 | CTSV (0.64) | CTSVCTSLSIRT2MEN1KMT2A | |
| SCHEMBL27568225 | 0.76 | CTSV (0.58) | CTSVCTSLSIRT2MAOBAKR1C3 | |
| SCHEMBL10983488 | 0.75 | CTSV (1.00) | CTSVCTSLSIRT2MEN1KMT2A | |
| SCHEMBL27322834 | 0.74 | MAOB (0.67) | CTSVCTSLSIRT2MAOBMEN1 | |
| SCHEMBL6899074 | 0.74 | MAOB (0.65) | MAOBMEN1KMT2ANPC1RAB9A | |
| SCHEMBL10934405 | 0.74 | SIRT2 (0.76) | CTSVCTSLSIRT2MAOBMEN1 | |
| SCHEMBL15233688 | 0.73 | RAB9A (0.64) | MAOBMEN1KMT2ANPC1RAB9A | |
| SCHEMBL31504435 | 0.73 | CTSV (0.56) | CTSVCTSLSIRT2PTK6 | |
| SCHEMBL21617259 | 0.73 | CTSV (0.56) | CTSVCTSLSIRT2PTK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783505-B1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2001-03-07 | — | — | EP | disclosed |
| US-5869485-A | Pyrrolo 2,3-d!pyrimidines and their use | NOVARTIS FINANCE CORP. (US) | 1999-02-09 | — | — | US | disclosed |
| EP-0783505-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | Novartis AG (CH) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996010028-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 1996-04-04 | — | — | WO | disclosed |