Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 1/20 | 0.60 |
| ▸ | CTSL | P07711 | 1/20 | 0.60 |
| ▸ | SIRT2 | Q8IXJ6 | 15/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.52 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4483532 | 0.89 | CTSV (0.74) | CTSVCTSLSIRT2LMNAMAPT | |
| SCHEMBL7835152 | 0.86 | CTSV (0.81) | CTSVCTSLSIRT2LMNAMAPT | |
| SCHEMBL7844457 | 0.85 | AKR1C3 (0.66) | CTSVCTSLSIRT2LMNAMAPT | |
| SCHEMBL7844996 | 0.79 | CDC25B (0.70) | LMNAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL27339343 | 0.78 | KMT2A (0.61) | LMNAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL11518974 | 0.77 | SYK (0.57) | LMNAMAPTKMT2ASMN1; SMN2PTK6 | |
| SCHEMBL7986906 | 0.76 | MAPT (0.54) | LMNAMAPTKMT2ASMN1; SMN2PTK6 | |
| SCHEMBL11780348 | 0.76 | POLB (0.67) | LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL30567367 | 0.76 | MAPT (0.68) | SIRT2MAPTKMT2ASIRT1 | |
| SCHEMBL848485 | 0.76 | MAPT (0.68) | SIRT2MAPTKMT2ASIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783505-B1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2001-03-07 | — | — | EP | disclosed |
| US-5869485-A | Pyrrolo 2,3-d!pyrimidines and their use | NOVARTIS FINANCE CORP. (US) | 1999-02-09 | — | — | US | disclosed |
| EP-0783505-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | Novartis AG (CH) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996010028-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 1996-04-04 | — | — | WO | disclosed |