Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2470240 | 0.86 | MAOA (0.61) | SIGMAR1OPRL1POLBOPRM1CYP3A4 | |
| SCHEMBL2465510 | 0.85 | SLC6A4 (0.61) | SIGMAR1OPRL1POLBCHRM2CHRM3 | |
| SCHEMBL10253807 | 0.84 | OPRL1 (0.50) | SIGMAR1OPRL1POLBOPRM1CYP3A4 | |
| SCHEMBL2701086 | 0.84 | SIGMAR1 (0.61) | SIGMAR1OPRL1CHRM2CHRM3KDM4E | |
| SCHEMBL3894897 | 0.81 | OPRL1 (0.73) | SIGMAR1OPRL1POLBCHRM2CHRM3 | |
| SCHEMBL2834848 | 0.81 | SLC6A4 (0.62) | SIGMAR1OPRL1POLBCHRM3LMNA | |
| SCHEMBL4712452 | 0.77 | OPRL1 (0.54) | SIGMAR1OPRL1POLBOPRM1CYP3A4 | |
| SCHEMBL2702173 | 0.77 | SLC6A3 (0.54) | SIGMAR1OPRL1POLBOPRM1CYP3A4 | |
| SCHEMBL8267914 | 0.76 | SIGMAR1 (0.62) | SIGMAR1POLBCHRM2CHRM3CYP2D6 | |
| SCHEMBL7831492 | 0.76 | NPFFR1 (0.54) | SIGMAR1POLBCHRM2CHRM3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087770-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-11-14 | — | — | EP | disclosed |
| EP-1087770-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-04 | — | — | EP | disclosed |
| US-6172076-B1 | HETEROCYCLE-SUBSTITUTED 1,3,8-TRIAZASPIRO(4,5)DECANE DERIVATIVES; TREATING ARTERIOSCLEROSIS | MERCK & CO., INC. | 2001-01-09 | — | — | US | disclosed |
| WO-1999065494-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-12-23 | — | — | WO | disclosed |