Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | EBP | Q15125 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004124 | 0.83 | BCHE (0.50) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL10191805 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL13339111 | 0.80 | MAPT (0.48) | SMN1; SMN2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL791938 | 0.77 | HTR1A (0.60) | HTR1AADRA1DADRA1AADRA1BSIGMAR1 | |
| SCHEMBL7004776 | 0.77 | HTR1A (0.49) | HTR1AADRA1DADRA1AADRA1BABCB1 | |
| SCHEMBL20970890 | 0.76 | HTR2A (0.62) | — | |
| SCHEMBL14835845 | 0.75 | ALOX5 (0.50) | HTR1AADRA1DADRA1AADRA1BSIGMAR1 | |
| SCHEMBL862597 | 0.75 | SIGMAR1 (0.52) | SIGMAR1EBPTMEM97 | |
| SCHEMBL7847500 | 0.74 | SMN1; SMN2 (0.45) | SMN1; SMN2 | |
| SCHEMBL19612479 | 0.74 | ABCB1 (0.53) | HTR1AADRA1DADRA1AADRA1BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714898-B1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-11-14 | — | — | EP | disclosed |
| CN-1046730-C | Pyrazolo [1,5-a ] pyrimidine derivatives | OTSUKA PHARMA CO LTD (JP) | 1999-11-24 | — | — | CN | disclosed |
| US-5707997-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-13 | — | — | US | disclosed |
| CN-1131948-A | Pyrazolo [1, 5-a ] pyrimidine derivatives | OTSUKA PHARMA CO LTD (JP) | 1996-09-25 | — | — | CN | disclosed |
| EP-0714898-A1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-06-05 | — | — | EP | disclosed |