Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6783457 | 0.91 | ITGB3 (0.45) | ALDH1A1HPGDSMN1; SMN2GPR139LMNA | |
| SCHEMBL7346550 | 0.89 | ITGB3 (0.40) | GPR139KMT2AITGB3ITGAVNPSR1 | |
| SCHEMBL7338356 | 0.86 | SMN1; SMN2 (0.44) | ALDH1A1SMN1; SMN2GPR139LMNAKMT2A | |
| SCHEMBL7340341 | 0.86 | F7 (0.41) | SMN1; SMN2GPR139LMNAKMT2AITGB3 | |
| SCHEMBL7341726 | 0.85 | GPR139 (0.42) | ALDH1A1GPR139LMNAKMT2AITGB3 | |
| SCHEMBL7823382 | 0.85 | MAPT (0.41) | ALDH1A1HPGDSMN1; SMN2LMNAITGB3 | |
| SCHEMBL7344055 | 0.85 | F7 (0.46) | ALDH1A1SMN1; SMN2GPR139MAPTF2 | |
| SCHEMBL3839471 | 0.85 | GPR139 (0.47) | GPR139KMT2AITGB3ITGAVF2 | |
| SCHEMBL7833456 | 0.84 | NPC1 (0.41) | ALDH1A1SMN1; SMN2GPR139LMNAKMT2A | |
| SCHEMBL7339495 | 0.83 | KMT2A (0.44) | ALDH1A1SMN1; SMN2GPR139LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |