Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.39 |
| ▸ | ITGAV | P06756 | 2/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.39 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.39 |
| ▸ | ITGB6 | P18564 | 2/20 | 0.39 |
| ▸ | ITGB8 | P26012 | 2/20 | 0.39 |
| ▸ | ITGA8 | P53708 | 2/20 | 0.39 |
| ▸ | F7 | P08709 | 4/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338356 | 0.93 | SMN1; SMN2 (0.44) | KMT2AMEN1SMN1; SMN2NPC1LMNA | |
| SCHEMBL7345189 | 0.92 | F2 (0.42) | KMT2AMEN1PLAUITGB3F7 | |
| SCHEMBL6780563 | 0.91 | ITGB3 (0.46) | KMT2AMEN1PLAUSMN1; SMN2NPC1 | |
| SCHEMBL7341726 | 0.91 | GPR139 (0.42) | KMT2AMEN1LMNAITGB3ITGB1 | |
| SCHEMBL3839471 | 0.90 | GPR139 (0.47) | KMT2AMEN1ITGB3ITGB1ITGAV | |
| SCHEMBL7836849 | 0.89 | PKM (0.44) | KMT2APLAUSMN1; SMN2NR1H4LMNA | |
| SCHEMBL7346550 | 0.87 | ITGB3 (0.40) | KMT2AMEN1ITGB3ITGB1ITGAV | |
| SCHEMBL7835622 | 0.87 | ITGB3 (0.42) | KMT2AMEN1ITGB3ITGB1ITGAV | |
| SCHEMBL7340341 | 0.87 | F7 (0.41) | KMT2AMEN1SMN1; SMN2LMNAITGB3 | |
| SCHEMBL7838264 | 0.87 | ITGB3 (0.51) | ITGB3ITGB1ITGAVITGA5ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |