Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 2/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.38 |
| ▸ | ITGAV | P06756 | 4/20 | 0.38 |
| ▸ | ITGB6 | P18564 | 4/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.38 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.38 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.38 |
| ▸ | ITGB8 | P26012 | 2/20 | 0.38 |
| ▸ | ITGA8 | P53708 | 2/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 3/20 | 0.36 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GPR139 | Q6DWJ6 | 4/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6773735 | 0.86 | TP53 (0.39) | PTPRCITGB3ITGAVITGB6ITGB1 | |
| SCHEMBL6778195 | 0.84 | ITGB3 (0.43) | ITGB3ITGAVITGB1ITGA5CASR | |
| SCHEMBL7838359 | 0.83 | PTPRC (0.38) | PTPRCITGB3ITGAVITGB6ITGB1 | |
| SCHEMBL6778844 | 0.82 | PTPRC (0.37) | PTPRCITGB3ITGAVITGB6ITGB1 | |
| SCHEMBL7835946 | 0.77 | ITGB3 (0.51) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL6782067 | 0.76 | ITGB3 (0.55) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL6776952 | 0.76 | ITGB3 (0.49) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL27486478 | 0.76 | GPR139 (0.44) | ITGB3ITGAVITGB1ITGA5F2 | |
| SCHEMBL3839471 | 0.76 | GPR139 (0.47) | ITGB3ITGAVITGB1ITGA5F2 | |
| SCHEMBL7832122 | 0.76 | ITGB3 (0.42) | ITGB3ITGAVITGB6ITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | disclosed |
| US-6028223-A | AN INTEGRIN ANTAGONISTS TREATING BONE DISORDER, PERIODONTAL DISEASE, OSTEOPOROSIS, HUMORAL HYPERCALCEMIA OF MALIGNANCY, PAGET'S DISEASE, TUMOR ANGIOGENESIS, DIABETIC RETINOPATHY, ARTHRITIS, SMOOTH MUSCLE CELL MIGRATION AND RESTENOSIS | G. D. SEARLE & CO. (US) | 2000-02-22 | — | — | US | disclosed |