Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 2/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.37 |
| ▸ | ITGAV | P06756 | 3/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.37 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.37 |
| ▸ | ITGB6 | P18564 | 3/20 | 0.37 |
| ▸ | ITGB8 | P26012 | 3/20 | 0.37 |
| ▸ | ITGA8 | P53708 | 3/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 5/20 | 0.36 |
| ▸ | F7 | P08709 | 3/20 | 0.36 |
| ▸ | GPR139 | Q6DWJ6 | 6/20 | 0.36 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6778241 | 0.87 | ITGB3 (0.46) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL6778195 | 0.86 | ITGB3 (0.43) | ITGB3ITGB1ITGAVITGA5CASR | |
| SCHEMBL6773735 | 0.85 | TP53 (0.39) | PTPRCITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL6778844 | 0.83 | PTPRC (0.37) | PTPRCITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL7835686 | 0.83 | PTPRC (0.39) | PTPRCITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL7835665 | 0.81 | ITGB3 (0.45) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL7341564 | 0.79 | GPR139 (0.41) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL3839471 | 0.78 | GPR139 (0.47) | ITGB3ITGB1ITGAVITGA5F2 | |
| SCHEMBL6776653 | 0.78 | ITGB3 (0.58) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL7341726 | 0.78 | GPR139 (0.42) | ITGB3ITGB1ITGAVITGA5ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |