Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831973 | 0.86 | KMT2A (0.55) | KMT2AHPGDMEN1SMN1; SMN2MAPK1 | |
| SCHEMBL7830685 | 0.86 | KMT2A (0.58) | KMT2AHPGDMEN1SMN1; SMN2MAPK1 | |
| SCHEMBL11730687 | 0.85 | HPGD (0.59) | KMT2AHPGDMEN1SMN1; SMN2MAPK1 | |
| SCHEMBL4490722 | 0.85 | KMT2A (0.64) | KMT2AHPGDMEN1SMN1; SMN2MAPK1 | |
| SCHEMBL4766008 | 0.83 | KMT2A (0.54) | KMT2AHPGDMEN1SMN1; SMN2MAPK1 | |
| SCHEMBL14038766 | 0.82 | KMT2A (0.56) | KMT2AHPGDMEN1SMN1; SMN2MAPK1 | |
| SCHEMBL19755863 | 0.81 | LOXL2 (0.54) | KMT2AHPGDMEN1SMN1; SMN2MAPK1 | |
| SCHEMBL8985073 | 0.80 | GSK3B (0.67) | KMT2AHPGDMEN1SMN1; SMN2C5AR1 | |
| SCHEMBL13932417 | 0.80 | KMT2A (0.48) | KMT2AHPGDMEN1SMN1; SMN2MAPK1 | |
| SCHEMBL4769071 | 0.80 | ALDH1A1 (0.60) | KMT2AMEN1SMN1; SMN2MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-5859014-A | USEFUL IN TREATMENT OF DISEASES INVOLVING DIRECTLY OR INDIRECTLY AN OBSTRUCTION OF THE LOWER URINARY TRACT, SUCH ASBENIGN PROSTATE HYPERPLASIA | SYNTEX (U.S.A.) INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |