Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7830685 | 0.94 | KMT2A (0.58) | KMT2ABCHEACHEHPGDSMN1; SMN2 | |
| SCHEMBL7835720 | 0.86 | KMT2A (0.69) | KMT2ABCHEACHEHPGDSMN1; SMN2 | |
| SCHEMBL7847653 | 0.84 | HPGD (0.51) | KMT2AHPGDSMN1; SMN2MEN1CYP3A4 | |
| SCHEMBL4771735 | 0.77 | BCHE (0.56) | KMT2ABCHEACHEHPGDSMN1; SMN2 | |
| SCHEMBL11196780 | 0.77 | KDM4E (0.49) | HPGDSMN1; SMN2C5AR1ALDH1A1LMNA | |
| SCHEMBL7830852 | 0.77 | CCNB2 (0.43) | KMT2ASMN1; SMN2MEN1C5AR1ALDH1A1 | |
| SCHEMBL7822006 | 0.77 | LGMN (0.44) | SMN1; SMN2C5AR1ALDH1A1LMNACCNB2 | |
| SCHEMBL7834893 | 0.76 | POLB (0.44) | SMN1; SMN2C5AR1MAPTCCNB2CDK1 | |
| SCHEMBL11730687 | 0.76 | HPGD (0.59) | KMT2AHPGDSMN1; SMN2MEN1MAPK1 | |
| SCHEMBL14038766 | 0.73 | KMT2A (0.56) | KMT2AHPGDSMN1; SMN2MEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-5859014-A | USEFUL IN TREATMENT OF DISEASES INVOLVING DIRECTLY OR INDIRECTLY AN OBSTRUCTION OF THE LOWER URINARY TRACT, SUCH ASBENIGN PROSTATE HYPERPLASIA | SYNTEX (U.S.A.) INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |